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Search Results for " glucosidase, β, acid "

Targets Recommended: Others

4

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T19181	Afegostat D-Isofagomine,Isofagomine	Others	Others
	Afegostat is a pharmacological chaperone that specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum with high affinity.
T19182	Afegostat D-Tartrate Isofagomine D-Tartrate,D-Isofagomine D-Tartrate	Others	Others
	Afegostat D-Tartrate is a pharmacological chaperone that specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum with high affinity.
T23653	Afegostat HCl Afegostat,AT-2101,Afegostat hydrochloride,AT2101
	Afegostat is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone. Afegostat inhibits GCase with K(i) ~30 nM for wild-type and mutant enzymes. Afegostat was an experimental drug for the treatment of certain forms of
T71476	Afegostat TFA
	Afegostat, aslo known as Isofagomine, and AT2101, was an experimental drug for the treatment of certain forms of Gaucher's disease. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone. FG inhibits GCase with K(i) ~30 nM for wild-type and mutant enzymes (N370S and V394L). Administration of IFG (30 mg/kg/day) to the mice homozygous for GCase mutations (V394L, D409H, or D409V) led to increased GCase activity in visceral tissues and brain...

化合物

Cat.No: T19181

Synonym: D-Isofagomine,Isofagomine

Target: Others

Afegostat D-Tartrate

Cat.No: T19182

Synonym: Isofagomine D-Tartrate,D-Isofagomine D-Tartrate

Target: Others

Cat.No: T23653

Synonym: Afegostat,AT-2101,Afegostat hydrochloride,AT2101

Cat.No: T71476

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05099	GBA/glucocerebrosidase Protein, Human, Recombinant (His) glucosidase, β, acid,GLUC,GCB,GBA...	Human	HEK293 Cells
	Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine production and metabolism are attractive therapeutic targets for treating mutant GBA-associated PD.
TMPY-01579	GBA3 Protein, Human, Recombinant (His) glucosidase, beta, acid 3 (gene/pseudogene...	Human	Baculovirus Insect Cells
	Cytosolic beta-glucosidase, also known as Cytosolic beta-glucosidase-like protein 1, GBA3, CBG and CBGL1 is a cytoplasm protein which belongs to theglycosyl hydrolase 1 family and Klotho subfamily. GBA3 / CBGL1 is a glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. GBA3 / CBGL1 is present in small intestine (at protein level). GBA3 / CBGL1 is expressed in liver, small intestine, colon, spleen and kidney. GBA3 / CBGL1 is down-regulated in r...

重组蛋白

GBA/glucocerebrosidase Protein, Human, Recombinant (His)

Cat.No: TMPY-05099

Species: Human

Expression System: HEK293 Cells

GBA3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01579

Species: Human

Expression System: Baculovirus Insect Cells

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